low hematocrit and hemoglobin during chemo

Increased levels of RBC can adversely affect the flow in the blood vessels. Machine to machine variation: There is a 2 to 3 %variation in various automated cell counters.Diurnal variations: Values are increased at 8 am while a little decreased at 8 pm.This is to compensate for the decreased availability of oxygen.

Smokers & Persons living in high altitudes typically have increased hemoglobin.

This decrease is due to a chronic state of overhydration On the contrary, RBC levels increase in pregnancy. A slight decrease in the hemoglobin and Hematocrit levels during pregnancy reflects the expanded blood volume. Pregnancy is the most common cause of increased fluid status, especially in women. Dehydration will result in the blood concentration resulting in falsely elevated levels, while overhydration shows falsely decreased levels.

Pregnancy: Plasma state can affect the levels of hemoglobin.

Increased levels are indicative of erythrocytosis, while that of decreased levels is indicative of anemia. When the RBC is of normal size and shapes, Hct values are usually three times that of hemoglobin. The levels of hemoglobin closely reflect that of Hematocrit and RBC count. Females have less than males, and young have more hemoglobin than the old. Levels of hemoglobin will vary as per the age and sex.

Erythropoiesis is the process of production of hemoglobin and RBC in the bone marrow. This production needs a specific stimulation from Erythropoietin (EPO). The factors which determine in the swing in the oxygen dissociation curve are pH, Co2, 2-3BPG, and temperatureīone marrow is the site of hemoglobin and RBC synthesis. However, not all the oxygen which is bound to the hemoglobin will be released.īinding and release of oxygen occur on the hemoglobin molecule is guided by the oxygen dissociation curve. When the hemoglobin reaches the tissues, the oxygen is released. Oxygen bind to the hemoglobin in the lungs. For example, an adult with 15 gm% of Hb will carry around 20 mg/dL of oxygen

Globin: contains two chains, an alpha chain, and a beta chain.ġgm% of Hb carries around 1.3mg/dl of oxygen.

Heme: Iron surrounded by a porphyrin ring.

Hemoglobin( Heme+Globin) contains two components It has a globular structure where iron is located centrally and 4 globular proteins, of which 2 form the alpha chains while the other 2 are the beta chains. Hemoglobin is a metalloprotein, a compound of heme ( iron and globin protein).

It helps in the transport of oxygen and carbon dioxide.

Hemoglobin is an oxygen-carrying protein. Clinical symptoms include headache and dizziness What is Hemoglobin? Polycythemia is a clinical condition where there are severe increases in the levels of hemoglobin. They will eventually decrease the Hb as they result in a faster breakdown of RBC. These conditions result in unstable RBC, which will break soon and eventually causes low hemoglobin. These clinical conditions are characterized by altered shapes and chains in the hemoglobin. Any abnormal increase in levels of hemoglobin increases the viscosity and hamper the flow. In contrast, polycythemia is a clinical condition with increased RBC and hemoglobin. Clinical features of anemia include weakness, fatigue, and palpitations.

Hemoglobinopathies: Sickle cell anemia, thalassemiaĪnemia is a common clinical condition that results from low hemoglobin.

Increased hemoglobin production: Polycythemia.

Hemoglobin is tested when your physician suspects

to screen and diagnose red cell disorders( sickle cell anemia, thalassemia ).

Hemoglobin is an integral component of complete blood counts(CBC). Testing determines the total amount present in the blood. It is the oxygen-carrying protein present in the blood.

Low hematocrit and hemoglobin during chemo